The good news upfront – 2 x 500 mg Panadol tabs every 4-6 hours for a few days is totally safe in adults with no known liver disease! The same dose is also safe in pregnancy.
This appeared a day or so ago:
Anatomy of a full-blown crisis for company that makes Tylenol (= Panadol In Australia)
Peter Loftus, Alyssa Lukpat and Sara Ashley O’Brien
The stakes are high – a direct assault on the brand by the US president could open up the company to legal challenges. Picture: Elizabeth Coetzee/WSJ
27 September, 2025
The chief executive of the company that makes Tylenol got a text message earlier this month that contained nothing but a single link to a Substack post.
In the post, a promoter of Covid-19 misinformation was connecting autism with acetaminophen, the active ingredient in Tylenol.
The text was from the nation’s top health official, Robert F. Kennedy Jr. At that moment, it was clear to CEO Kirk Perry that his efforts to convince Kennedy that there was no science behind such claims had failed.
On Monday, Perry faced a full-blown crisis. In an extraordinary public announcement that contradicted widespread medical consensus and even his own top health advisers, President Donald Trump warned that acetaminophen is a potential cause of autism, and urged expecting mothers to “tough it out” without the drug if they could.
“Taking Tylenol is not good,” the President told the world as Kennedy, the Health and Human Services secretary, looked on.
That claim has sent the medical establishment into panic mode. And it’s thrown Kenvue, the company that makes Tylenol, into crisis – just 70 days into Perry’s tenure as CEO.
Tylenol set the gold standard for corporate crisis management in 1982 after people died from taking its pain medication that had been tampered with and laced with cyanide. In a case now studied by business students and companies everywhere, the brand won back public trust with a quick recall, a redesign of its bottles to be tamper-resistant, and lots of coupons.
The stakes this time may be even higher. A direct assault on the brand by the president of the US could open up the company to legal challenges. That is one reason that Kenvue’s stock hit an all-time low this past week. Perry and his team are also grappling with the possibility that millions of pregnant women around the world will avoid Tylenol when they have fevers, infections or other symptoms.
Leaving those ailments untreated could increase birth defects and could itself contribute to a rise in autism, according to leading medical organisations and regulators in other countries.
Donald Trump speaks about autism at the White House during the week. Picture: AFP
Perry has been talking with his friend, pastor Brian Tome of Crossroads Church in Cincinnati, regularly over the past few days. Tome has reminded Perry of Bible verses that can be encouraging in hard times, and that Jesus said that his followers should “take up his cross daily, and follow me”.
“He doesn’t like what he’s going through,” Tome says of Perry. “He certainly wishes it was different, but I’m not seeing any bitterness in him and I think that’s because of his faith.”
Raised in Detroit by young parents who were assembly workers for Ford, Perry was the first in his family to graduate from college. He attended the University of Cincinnati after working at Wendy’s for about a year and a half to save up the tuition.
He met his wife, Jacki, at a Piggly Wiggly grocery store in Ohio when he was 18. They married in his senior year of college and have four children.
He has frequently said he leaned on religion when his then six-year-old daughter was being treated for kidney cancer. When a doctor told him and his wife that their daughter’s emergency colon surgery was successful, he dropped to the floor and wept. He said he realised God wasn’t making his daughter suffer, but God was with them when bad things happened.
Perry, 59, retired earlier this year after a career in marketing that included stints at Google and Procter & Gamble. His last job had been as CEO of market-research firm Circana. He was excited to coach high-school football, do mission work with his wife and hunt elk with friends. Then Kenvue called.
“Quite possibly the shortest retirement ever,” he wrote on LinkedIn this northern summer. Kenvue became independent two years ago when Johnson & Johnson split off its consumer-health unit. In addition to Tylenol, the Summit, New Jersey, company includes other famous brands such as Band-Aid, Johnson’s Baby Shampoo and the Neutrogena and Aveeno lines of shampoos and creams. J&J said the name Kenvue signified knowledge and sight.
Mother of autistic children slams Trump's autism comments
From the start, Kenvue fought attacks linking Tylenol to autism, but it didn’t get much attention. Some 500 lawsuits had been filed against Kenvue and other makers of acetaminophen products in federal courts, alleging that use of the drug during pregnancy caused autism and attention-deficit/hyperactivity disorder in children.
The lawsuits were based on a series of studies suggesting an association between acetaminophen and autism, though other studies had found no association.
An expert witness for plaintiffs was Dr Andrea Baccarelli, dean of the faculty of Harvard T.H. Chan School of Public Health. A federal judge in New York concluded that Baccarelli’s opinions about causation weren’t admissible in the litigation.
Kenvue argued in court that there was no credible evidence of a causal link. The judge sided with Kenvue in December 2023 and the cases were dismissed, though plaintiffs are appealing and some lawsuits have been filed in state courts.
Tylenol continued to sell well, though Kenvue’s beauty division was floundering. In July, the board ousted its CEO, a J&J veteran who had led the company since the spinoff, and brought in Perry while it searched for a permanent replacement.
Perry thought his challenge would be to turn around the beauty brands. On his first call with analysts to discuss quarterly results on August 7, he said he needed to streamline the product portfolio because the company made too many items that were generating only a small fraction of its sales.
Tylenol packages are seen in a pharmacy in Houston, Texas. About 500 lawsuits had been filed against its maker Kenvue and other makers of acetaminophen products in federal courts, alleging that use of the drug during pregnancy caused autism and attention-deficit/hyperactivity disorder in children. Picture: AFP
The company embarked on a review of strategic alternatives that some analysts say may include selling some assets – or even the entire company. The review is still under way.
A week later, there was an early sign of the trouble to come. A journal called BMC Environmental Research on August 14 published the results of an analysis by researchers from Harvard’s public-health school and other institutions.
They analysed past studies on the topic and said a majority of the studies found an association between acetaminophen and neurodevelopmental disorders including autism, though they stopped short of saying there was definitive evidence of causation.
The study was co-authored by Baccarelli, the Harvard dean whose expert testimony had been thrown out in court.
Baccarelli discussed his findings in recent weeks with Kennedy and Dr Jay Bhattacharya, the director of the National Institutes of Health, Baccarelli said in a statement provided by Harvard. Those phone calls took place in early September, a university spokeswoman added.
Kennedy’s autism views are based on “his ideology”, not science
“We've created an association that is false: The lack of vaccines and the lack of Tylenol is somehow associated with...
Kennedy reached out to Kenvue to set up a meeting with Perry. They arranged to meet the week of September 8. Days before the meeting took place, The Wall Street Journal reported that Kennedy was also working on a report that would say pregnant women’s use of Tylenol was potentially linked to autism.
In the meeting with Kennedy, Perry and Kenvue’s chief scientific officer, Caroline Tillett, made their case that there was no clear evidence linking autism and acetaminophen, and that there weren’t good alternatives to acetaminophen during pregnancy.
Kennedy agreed that there weren’t safe alternatives, according to people familiar with the matter. He discussed doing additional research, and asked that the executives set up follow-up meetings with Dr Mehmet Oz, the head of the Centres for Medicare and Medicaid Services, and Bhattacharya.
Centres for Medicare & Medicaid Services administrator Dr Mehmet Oz speaks in the Roosevelt Room of the White House during the week along with Mr Trump. AP Photo/Mark Schiefelbein
Perry and Tillett came away from the meeting thinking it had gone well, and that Kennedy’s request to set up additional meetings with Oz and Bhattacharya was a good sign that they could work with the administration.
But days later, Kennedy texted Perry the link to a Substack written by Sayer Ji, the founder of an alternative-health information platform called GreenMedInfo who has spoken at events alongside prominent members of Kennedy’s Make America Healthy Again movement. Ji has contended that vaccinations, prenatal ultrasounds and “stressors” from cesarean sections are among other factors that can increase autism risk.
Perhaps the meeting hadn’t been as much of a success as they’d thought. The Kenvue board of directors held a regularly scheduled meeting the week of Sept. 15. Perry and his management team briefed the board on Kennedy’s impending autism report, but there wasn’t much discussion, according to a person familiar with the matter. Certainly nothing that painted it as anything other than routine business.
00:05 / 00:53
Trump tying Tylenol to autism 'not based in fact': autism expert
U.S. President Donald Trump on Monday (September 22) linked autism to childhood vaccines and also to the use of...
Trump started to tee up his autism announcement a few days later, announcing on Friday, Sept. 19, that he was planning to hold a press conference. That Sunday, in a packed football stadium for the memorial service for assassinated conservative activist Charlie Kirk, Trump promised a Monday announcement about “an answer to autism”.
The company issued a statement, worded more strongly than its prior public comments. Science clearly shows that taking acetaminophen doesn’t cause autism, it said.
“We strongly disagree with any suggestion otherwise and are deeply concerned with the health risk this poses for expecting mothers.”
Kenvue on Monday cancelled its meetings with Oz and Bhattacharya.
Just before 5pm local time on Monday, at the start of his press conference televised from the White House’s Roosevelt Room, President Trump tripped up pronouncing acetaminophen as he said it was associated with a “very increased” risk of autism.
The President switched to referring to it as Tylenol for the rest of the news conference. “So taking Tylenol is not good, all right, I’ll say it. It’s not good,” he said, as Kennedy stood by.
President Donald Trump speaks in the Roosevelt Room of the White House during the week as Health and Human Services Secretary Robert F. Kennedy Jr listens. AP Photo/Mark Schiefelbein
The President acknowledged that he was diverging from the health leaders he chose to guide him: “Bobby wants to be very careful with what he says, ” Trump said, referring to Kennedy. “But I’m not so careful with what I say.”
The Wall Street Journal
Trump autism claims spark debate about modern chemical exposure
The Therapeutic Goods Administration has advised women paracetamol is safe to take during pregnancy despite Donald Trump linking the medication to increased autism rates.
Mark Butler has asked for advice on Donald Trump's link of the use of Panadol during pregnancy with autism.
5:36 AM September 24, 2025
One of Australia’s foremost researchers into neuroscience and the developing brain has urged medical bodies not to dismiss out of hand concerns around paracetamol use in pregnancy despite no causative link between the drug and autism being established.
The Florey Institute for Neuroscience and Mental Health’s division head for early brain science department and head of the neuroepidemiology research group, Anne-Louise Ponsonby, said the Trump administration had opened up an important conversation about the interplay between people’s significant exposure to environmental toxins in modern societies and its complex interplay with genetics.
Although Australia’s health regulator has advised women paracetamol is safe to take during pregnancy, Professor Ponsonby said the consistent findings across a string of high-quality studies that reported an association between paracetamol use in pregnancy and autism rates in children should not be dismissed completely.
“I think it’s a good idea to look at all types of manufactured chemicals and to review how much they’re needed for pregnant women,” Professor Ponsonby said. “The data is not causal evidence, but there are some positive links between Panadol and autism, and they do deserve further investigation.”
The US Department of Health issued a fact sheet on Tuesday pointing to a number of large-scale cohort studies that reported associations between in-utero exposure to paracetamol and later diagnoses of autism spectrum disorder, the incidence of which has risen markedly in the past two decades worldwide. It also acknowledged conflicting family-based studies which dismissed any association but pointed to Harvard and Mt Sinai university criticisms of these studies.
A Harvard study published in August this year reported that eight studies analysed paracetamol use in pregnancy and the development of autism, with five reporting positive associations. Evaluating those studies, the study said: “ultimately, there was strong evidence of a relationship between prenatal acetaminophen use and increased risk of ASD in children”.
Australia’s medicines regulator, the Therapeutic Goods Administration, said it had no current safety investigations for paracetamol and autism, or paracetamol and neurodevelopment disorders more broadly. Acetaminophen is known as paracetamol in Australia and many other countries.
“Paracetamol remains Pregnancy Category A in Australia, meaning that it is considered safe for use in pregnancy,” the TGA said.
Pregnancy Category A applies to drugs which have been taken by a large number of pregnant women and women of child-bearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the foetus having been observed.
The TGA’s present advice is that paracetamol can be used during pregnancy if clinically needed but should be used at the lowest effective dose for the shortest possible time. It classifies any risk to babies from paracetamol use by mothers during pregnancy as “remote” but urges women to discuss the use of the medication with their doctor.
Australia’s Health Minister Mark Butler had asked the TGA to provide advice on the use of paracetamol after Mr Trump flagged his announcement on the drug.
Professor Ponsonby said that while not causative, the association between autism spectrum disorder (ASD) and paracetamol across several studies might reflect that the development of autism involved a complex interplay of environment and genetics and rising incidence of the condition could not be solely explained by more frequent diagnosis.
“Multiple genes and multiple environment factors contribute to autism as it is a multifactorial disease,” Professor Ponsonby said. “At least part of the rise in incidence is thought to reflect a real increase in cases – driven in part by modern environment.
“Several key areas of evidence deserve attention: the interplay of genetic and environmental factors; consistent associations between ASD and air pollution, and links to toxic chemicals like bisphenol-A, PFAS and pesticides.”
Professor Ponsonby said these kinds of findings highlighted the need for deep molecular studies to identify causation. She said it might not be the drug itself but the underlying reason for using the drug that may be significant.
The Australian Academy of Sciences described evidence of any possible link between paracetamol and autism as weak.
“There is no causal evidence that paracetamol causes autism,” the AAHMS said in a paper on the issue. “Large, high-quality population studies do not find a causal relationship between paracetamol use and autism.”
The academy stressed that letting a high fever continue during pregnancy presented a much greater risk than using the medicine.
The American College of Obstetricians and Gynaecologists says acetaminophen is safe to use in pregnancy, though it recommends that pregnant women consult with their doctors before using it, as with all medicines.
“In more than two decades of research on the use of acetaminophen in pregnancy, not a single reputable study has successfully concluded that (its use) in any trimester of pregnancy causes neurodevelopmental disorders in children,” the American O & G college said.
The parent company of Tylenol’s maker also backed the product’s safety.
“We believe independent, sound science clearly shows that taking acetaminophen does not cause autism,” said a spokeswoman for Kenvue, the parent company of Tylenol’s maker. “We strongly disagree with any suggestion otherwise and are deeply concerned with the health risk this poses for expecting mothers.”
The National Institutes of Health in the US is leading a report on the causes of autism that was expected to be a review of existing scientific literature and be released on September 29, according to people familiar with the matter. It is unclear whether the full report will still be released, or when.
Mr Trump said autism rates have increased from one in 20,000 to one in 12 among boys in some populations. He also said there was “no autism” among the Amish, who he said don’t take medications.
Mr Kennedy also warned against Tylenol use for young children. “Prudent medicine suggests caution,” he said.
Here is a link:
You really have to wonder about all this: ! Taking too much Panadol is dangerous and if you take too much it can cause liver failure and death. (Risk is only if an adult takes 20+ tablets all at the same time!) Taking 2 tables every 3-4 hours for a day or two for pain or fever is totally safe!
To say again, like most approved drugs, taken as directed (2 x 500mg tabs every 4-6 hours) Panadol is totally safe and good for fever and mild pain.
All the rest is a beat up – although people with known liver disease should ask their doctor for their recommendations as to dose! to be sure....
David.