This appeared a few days ago along with a reminder a report on the whole saga is due in September this year:
The Observer Coronavirus
Analysis
AstraZeneca’s Covid vaccine is no more – but its
remarkable success must not be forgotten
Robin McKie Science editor
Although
dogged by controversy, the firm’s coronavirus jab saved the lives of millions
and helped avert humanitarian crises in nations unable to access costly
alternatives
Sun 12 May
2024 00.29 AESTFirst published on Sun 12 May 2024 00.26 AEST
Last week’s
announcement that AstraZeneca
would no longer market its Covid vaccine brings an end to one of the
century’s most remarkable medical stories. Created within a year of the arrival
of the pandemic, the AZ vaccine was cheap, easily stored and transported, and
helped stave off humanitarian crises in Asia and Latin America, where many
countries could not afford the more expensive mRNA vaccines that were being
snapped up by rich western nations. It is estimated that it saved 6.3 million
lives in 2021 alone.
Yet from the
start the vaccine – created by research teams led by Professor Andy Pollard and
Professor
Sarah Gilbert at the Oxford Vaccine Centre – was dogged by controversy. It
was linked
to blood clots, US observers criticised protocols for its trials, and
French president Emmanuel Macron claimed it was “quasi-ineffective” for people
over 65. In fact, the vaccine is particularly effective for the elderly.
In very rare
cases, the AZ vaccine can cause blood clots. According to the British Heart
Foundation, one study in the BMJ showed that for every 10 million people
vaccinated with AstraZeneca
there would be a total of 73 extra cases of blood clots. By contrast 10 million
Covid cases would trigger thousands of extra blood clot cases.
Many of the
anxieties about the vaccine stemmed from national self-interests. However,
others derive from the nature of vaccines themselves, and this raises issues
that are likely to re-emerge with
the arrival of any new pandemic in coming years, scientists have warned.
A vaccine is
unlike any other type of medicine because it works by stimulating a person’s
anti-pathogen defences, arming them in advance of a future infection. However,
this preparation goes beyond helping one individual and can aid the general
population, a point stressed by Professor Stephen Evans, of the London School
of Medicine and Tropical Hygiene.
“If I take a
preventative drug – such as a statin – then I am the only one who benefits,”
said Evans. “However, there are people who cannot mount responses to a vaccine
because they are ill or have a weakened immune system. They remain vulnerable.
However, if you can build up herd immunity by ensuring the maximum number of
people are inoculated, virus levels will drop and the vulnerable will be
protected. If we believe we have responsibilities to help others, being
vaccinated achieves that. There are moral concerns about being inoculated, in
other words.”
Convincing
the public – which has witnessed a rise in anti-vax propaganda in recent years
– of this may not be easy. In addition, there is a second crucial difference
between standard medical treatments and vaccines, added Professor Sir David
Spiegelhalter, of the University of Cambridge. “We never know the identities of
those who benefit [from a vaccine] – they are ‘statistical’ people – while
those who are harmed can be named and their stories told.”
AstraZeneca’s
Covid vaccine provides an example. We only know those who were harmed by it but
cannot pinpoint those who benefited. Again, this makes it trickier to pinpoint
a vaccine’s success and assure people of its efficacy. “To a certain extent,
you can get round this and assess the impact of Covid vaccines by looking at
the deaths of frontline workers in the health service during the pandemic’s
early days,” added Evans. “Hundreds died, but if we had had a vaccine then it
is now clear most would probably have survived.”
Most
virologists and vaccine experts agree: when you look at the AstraZeneca vaccine
from a global perspective, it probably benefited tens of millions of people,
preventing deaths and reducing long-term consequences of Covid. It was a
remarkable success, yet its passing has been marked by many who stressed its
side-effects but never touched on its achievements.
“The paradox
of vaccines is that people forget how important they are,” said Professor Adam
Finn, of Bristol University. “They are like democracy. You enjoy it for a while
and then forget how important it is to preserve it. It’s a problem.”
On the other
hand, it is also clear politicians and officials will have to be careful about
the claims they make, added Fiona Fox, head of the Science Media Centre.
“Public trust in vaccines will come from open and honest communication. The
benefits massively outweigh the risks as they did with this vaccine.
“But you
won’t win any arguments by claiming that vaccines are 100% safe or running for
the hills at the first reports of problems, which unfortunately too many
government and NHS communications officers tend to do.
Downplaying
risks is always tempting when you need people to take a mostly safe vaccine but
it’s ultimately self-defeating because it erodes trust in the longer term.”
Robin McKie
and science and environment editor for the Observer
Here is the
link:
https://www.theguardian.com/world/article/2024/may/11/astrazeneca-covid-vaccine-jab-coronavirus-saved-lives-humanitarian-crises
If ever there was a case of perfection being the enemy of
the very good this saga has to be it.
I remember the excited debate about how many side-effect
related deaths were acceptable in the context of a pretty safe vaccine and a
rising death toll from the virus way back then, Fortunately sanity prevailed
with the at-risk populations until the Pfizer vaccine could be made and
imported in adequate quantities.
Looking back it seems we could have steamed forward with A-Z
and lost very few lives and saved a good few lives down the track.
Has anyone seen a decent review of the whole COVID-19 episode
and the response. It would make interesting reading now!
This video
will remind you of how we were thinking at the time:
https://www.youtube.com/watch?v=KtSz7w_TaEc&ab_channel=9NewsAustralia
Here is also a link to the Federal Government Inquiry which is due to report by September 2024.
https://www.pmc.gov.au/resources/commonwealth-government-covid-19-response-inquiry-terms-reference
Commonwealth Government COVID-19 Response Inquiry terms
of reference
The purpose of the Commonwealth
Government COVID-19 Response Inquiry (the Inquiry) is to identify lessons
learned to improve Australia’s preparedness for future pandemics.
Scope
The Inquiry will review the Commonwealth Government’s response to the
COVID-19 pandemic and make recommendations to improve response measures in the
event of future pandemics. It will consider opportunities for systems to more
effectively anticipate, adapt and respond to pandemics in areas of Commonwealth
Government responsibility.
The Inquiry will adopt a whole-of-government view in recognition of the
wide-ranging impacts of COVID-19 across portfolios and the community. Specific
areas of review may include, but are not limited to:
- Governance
including the role of the Commonwealth Government, responsibilities of
state and territory governments, national governance mechanisms (such as
National Cabinet, the National Coordination Mechanism and the Australian
Health Protection Principal Committee) and advisory bodies supporting
responses to COVID-19.
- Key
health response measures (for example across COVID-19 vaccinations and
treatments, key medical supplies such as personal protective equipment,
quarantine facilities, and public health messaging).
- Broader
health supports for people impacted by COVID-19 and/or lockdowns (for
example mental health and suicide prevention supports, and access to
screening and other preventive health measures).
- International
policies to support Australians at home and abroad (including with regard
to international border closures, and securing vaccine supply deals with
international partners for domestic use in Australia).
- Support
for industry and businesses (for example responding to supply chain and
transport issues, addressing labour shortages, and support for specific
industries).
- Financial
support for individuals (including income support payments).
- Community
supports (across early childhood education and care, higher education,
housing and homelessness measures, family and domestic violence measures
in areas of Commonwealth Government responsibility).
- Mechanisms
to better target future responses to the needs of particular populations
(including across genders, age groups, socio-economic status, geographic
location, people with disability, First Nations peoples and communities
and people from culturally and linguistically diverse communities).
The Inquiry will consider the findings of previous relevant inquiries and
reviews and identify knowledge gaps for further investigation. It will also
consider the global experience and lessons learnt from other countries in order
to improve response measures in the event of future global pandemics.
The following areas are not in scope for the Inquiry:
- Actions
taken unilaterally by state and territory governments.
- International
programs and activities assisting foreign countries.
Independent Panel
The Prime Minister has appointed an Independent Panel of three eminent
people to conduct the Inquiry. The Independent Panel will consult with relevant
experts and people with a diverse range of backgrounds and lived experience.
Taskforce
A Taskforce within the Department of the Prime Minister and Cabinet will
support the Independent Panel.
Public consultation
Public consultation will be completed during the Inquiry on the substance of
the issues outlined in the Terms of Reference. The Independent Panel may invite
and publish submissions and seek information from any persons or bodies.
Consultation will take place across Australia with:
- Key
community and other stakeholders reflecting a diversity of backgrounds
- Experts
- Commonwealth
Government and state and territory government agencies
- Members
of the public
Final Report
The Independent Panel will deliver a Final Report to Government including
recommendations to the Commonwealth Government to improve Australia’s
preparedness for future pandemics by the end of September 2024.
----- End Quote:
This will make fascinating
reading I am sure - and not all that far away! I wonder how 'warts and all' it will be?
David.