Quote Of The Year

Timeless Quotes - Sadly The Late Paul Shetler - "Its not Your Health Record it's a Government Record Of Your Health Information"

or

H. L. Mencken - "For every complex problem there is an answer that is clear, simple, and wrong."

Wednesday, July 09, 2025

If Ever There Was A Problem That Needed To Be Better Addressed This Could be It!

This appeared last week:

Silent killer: older Australian men are experiencing loneliness more than ever

A group of Australians at special risk of experiencing loneliness is older men. Yet most people – doctors included – don’t recognise the huge effect it is having on their lives and health.

Steve Robson

There’s a condition that can take years off your life and set you up for a raft of medical problems. Older men are most at risk for the condition and, at the moment, we’re in an escalating epidemic of it. Yet most people – doctors included – don’t recognise the huge effect it is having on our lives and health.

That condition is loneliness.

There is strong evidence that Australians are experiencing loneliness more than ever. A group at special risk is older men – with the decade from age 55 to 64 being a time of special risk according to recent statistics from the Australian Institute of Health and Welfare.

The institute’s figures point to almost one Australian adult in six experiencing prolonged loneliness. This is very similar to findings from countries such as Norway and the United States.

Indeed, so concerning is the global trend to loneliness that the World Health Organisation has described the situation as a major public health concern.

For these reasons the Australian organisation Ending Loneliness Together is calling for a national strategy to address the problem.

Aside from the health and compassionate concerns society should have about the “epidemic” of loneliness, economic research from Australia suggests that the health effects of loneliness may cost the economy as much as $2.7bn every year.

All of us need human connection not only to thrive but also to survive. Loneliness is the sometimes intense feeling of being alone or separated from others. While social isolation is closely related, it is possible – indeed common – to be lonely in the midst of many people.

Loneliness can be miserable for people to experience, but ill health flowing from being lonely can make everything worse.

It is startling to realise that long-term loneliness increases your chance of an early death by 26 per cent – the same effect as smoking 15 cigarettes a day.

So concerning are the health effects of loneliness that the US National Academies of Sciences has warned that “social isolation presents a major risk for premature mortality, comparable to other risk factors such as high blood pressure, smoking, or obesity.”

Loneliness now has been linked to illnesses such as heart disease and stroke, diabetes, mental health conditions such as depression and anxiety – even suicidality – as well as alcohol misuse and other additions. Dementia and other cognitive problems also are known to flow from long-term loneliness.

Why are we seeing such a wave of loneliness and health consequences flowing from it?

There is no doubt that the pandemic increased social isolation for many people, but loneliness was an issue before Covid-19 took to the stage. Part of the reason is that Australians are ageing and many of us are relying on digital connection rather than direct human contact.

Things that can have a powerful effect on causing loneliness including loss of mobility and difficulties in moving around. Untreated problems with vision or hearing are major contributors as people lose confidence in connection and communication.

Living in isolation has become an increasing trend in Australia. This is made worse if people have problems accessing transport or if they lack social support with getting out of their home. Cost-of-living issues are seeing many older Australians forgoing trips out and social events or joint meals.

The loss of a life partner – either their death or a need for care in a hospital or other care setting – can be very isolating. Divorce and relationship breakdowns can have a severe effect both on mental health and other friendship groups.

People already experiencing failing health, and those with a disability – especially Australians living in rural areas – may be at particular risk. People without children are another increasing trend, and those who have problems with social media connection.

Accepting that loneliness is a common problem for many people in our community, and that it has enormous potential effects on individual health and the broader economy, it may surprise you to learn that the medical research on what to do about loneliness is scant indeed.

Recognising these risks, it is vitally important that if you are experiencing loneliness that you let your doctor know. There should be no shame in talking about how you feel and how loneliness is affecting you. Your doctor needs to know.

That said, much of the solution clearly is beyond the realm of medicine alone. The US National Institute of Ageing has some excellent tips on managing loneliness. The critical first step is recognising the problem, understanding that is it common, and that it puts you at risk.

It is easy to neglect self-care when you’re lonely. As basic as these things seem, focusing on sleep, gentle physical activity, and eating healthily are an important start. Make sure you work with your doctor on this if you have been neglecting your health for a long time.

Re-connecting can be a challenge for many lonely people – it is very easy to lose confidence.

Volunteering can be a powerful way of giving yourself back a sense of purpose and meeting and building relationships with like-minded people. In fact, there is research to support the effects of volunteering in boosting your mood and strengthening your mind and body.

Recognise that everyone – all of us – seeks human connection. Make the time to call, text, or even write to family, friends or neighbours. So often you’ll be surprised how people will respond.

Think about joining a walking club, a church or other faith-based group, and check with local community organisations.

If you’re an older Australian man then you’re in a risk group for this most pernicious of conditions. Loneliness can affect anyone at any age, though. It can be tough to admit it has entered your life, but recognising it can save your life.

Steve Robson is professor of obstetrics and gynaecology at the Australian National University and former president of the Australian Medical Association. He is a board member of the National Health and Medical Research Council and a co-author of research into outcomes of public and private maternity care.


This column is published for information purposes only. It is not intended to be used as medical advice and should not be relied on as a substitute for independent professional advice about your personal health or a medical condition from your doctor or other qualified health professional.

Here is the link:

https://www.theaustralian.com.au/health/mental-health/silent-killer-older-australian-men-are-experiencing-loneliness-more-than-ever/news-story/4ce2ac566b2e21d536c1ab95ea79394d

I am not sure this is a problem confines to men – but whoever it affects on would hope for some quality help – especially to make the older years more contents and rich!

There is little doubt e are not doing enough at present and that there is decent room for improvement.

There are a lot of lonely people out there sadly…..

David.

Tuesday, July 08, 2025

We Can All Do Without This Sort Of Thing Happening In Australia!

This notes the reported goings on from a day or so ago in Melbourne:

Netanyahu demands action over ‘antisemitic hate crimes’ in Melbourne

Ronald Mizen Political correspondent

Jul 6, 2025 – 1.08pm

Israeli Prime Minister Benjamin Netanyahu has labelled a spate of attacks in Melbourne over the weekend antisemitic hate crimes and urged authorities to pursue those responsible to the fullest extent of the law.

After an arson attack on an East Melbourne synagogue and protests inside an Israeli restaurant on Friday night, and vandalism of the offices of a military-linked engineering firm early on Saturday morning, Netanyahu took to social media to demand action.

“The reprehensible antisemitic attacks, with calls of ‘death to the IDF’ and an attempt to attack a place of worship, are severe hate crimes that must be uprooted,” he said in a statement posted to social media.

Writing in The Australian Financial Review on Sunday, Jewish community spokesman Paul Rubenstein said such attacks were no longer shocking Australians and were “increasingly seen as part of the landscape – tragic, yes, but somehow expected”.

The NSW chairman of the Australia/Israel & Jewish Affairs Council said that “should terrify us all”.

“By failing to grasp the seriousness of what is unfolding, Australia’s political and civic leaders have left the Jewish community standing alone. This abdication of responsibility has sown deep moral confusion. It has set us on a perilous path – one history warns us never ends well,” Rubenstein said.

Home Affairs Minister Tony Burke declined to be drawn into a political spat, instead calling for unity. He echoed Rubenstein’s sentiment that what starts with words, “rarely ends with words”.

Burke labelled the arson attack on the synagogue in Melbourne’s east an “attack on all Australians” and sent a clear message to Australia’s Jewish community.

“You belong in Australia, you are welcome in Australia, and the Australian government has come here immediately to stand in solidarity with you,” he said after a visit to the synagogue on Sunday morning.

The Coalition demanded Prime Minister Anthony Albanese convene a meeting of the national cabinet to address the issue “with urgency”.

“There’s a number of things the government could be doing, yet we’re sitting here today discussing a horrible attack,” Coalition frontbencher Melissa McIntosh told the ABCs Insiders program.

Firefighters swiftly responded to the arson attack in which the door of the building was set alight while worshippers were inside. A NSW man has been charged following the incident.

Detectives from Victoria Police allege the 34-year-old man was seen walking through Parliament Gardens before entering the grounds of the synagogue on Albert Street at about 8pm.

“The man allegedly poured a flammable liquid on the front door of the building and set it on fire before fleeing the scene on foot in a westerly direction along Albert Street,” police said.

“There were approximately 20 people inside the synagogue at the time of the incident, taking part in Shabbat.”

Police confirmed everyone evacuated from the rear of the building and no one was injured. The man from Toongabbie, in western Sydney, was arrested in the Melbourne CBD on Saturday at about 8.15pm.

“He was interviewed by detectives and charged with reckless conduct endanger life, reckless conduct endanger serious injury, criminal damage by fire, and possess a controlled weapon,” police said.

He was due to appear in the bail and remand court on Sunday.

Under pressure to guarantee such attacks never occur again, Burke said part of the reason for the swift arrest was because of investments in CCTV under funding grants from the Albanese government.

“In terms of additional security measures, that was largely led by Mark Dreyfus [in the last parliament and] has been part of the story of this offender being captured so quickly,” he told reporters.

“People should be safe wherever they go in Australia, and the Australian dream, of this country, is [that] no matter where you come from in the world, no matter what your heritage is, we stand together, we welcome each other, and we do not import hatred and violence from overseas to life in Australia.”

Also on Friday night, police responded to a group of about 20 people, some masked and wearing Palestinian keffiyeh scarves, entering the CBD Israeli restaurant Miznon. Video footage from the Miznon incident shows diners screaming in fear inside the Hardware Lane restaurant.

Here is the link:

https://www.afr.com/politics/federal/netanyahu-demands-action-over-antisemitic-hate-crimes-in-melbourne-20250706-p5mcts

There is commentary here also:

Opinion

Tragic shift on antisemitism should terrify us all

If we cannot defend the safety and dignity of Jews in Australia today, we will not be able to defend the idea of a tolerant, inclusive, multicultural Australia tomorrow.

Paul Rubenstein Community leader

Jul 6, 2025 – 11.20am

When a synagogue is set on fire in East Melbourne, when diners at an Israeli-owned restaurant are violently assaulted by antisemitic thugs, the response should be national outrage. These are the kinds of attacks that ought to shake a country to its core.

But they don’t. Not any more.

Because these attacks are no longer treated as aberrations. They are increasingly seen as part of the landscape – tragic, yes, but somehow expected. And that shift should terrify us all.

The scorched door of the East Melbourne Synagogue after an anti-Israel protester set it alight on Friday evening.  Christopher Hopkins

Since October 7, 2023, Australia’s Jewish community has felt the ground shift beneath it. What once felt solid – our place in a tolerant, multicultural democracy – has been profoundly undermined. We hear the standard declarations that antisemitism has “no place” in Australia. But in practice, it has found one. It is growing stronger, louder, and more brazen by the day.

This is no longer just a campaign of intimidation against Jews. It is part of a broader assault on tolerance itself. The public space has become fertile ground for dangerous and false narratives: that Israel is colonialist, racist and genocidal. These are not simply criticisms of a nation-state – they form a grand, dehumanising accusation: that Israel, and by extension Jews, are inherently evil.

This rhetoric is not abstract. When protesters chant “Globalise the intifada”, they are not calling for peaceful reform – they are calling for violent revolution.

When crowds shout “Death to the IDF”, they are not voicing foreign policy concerns. They are issuing a threat: that Jews have no right to self-defence and should face mass slaughter at the hands of those who proudly call for it.

This is not free speech. It is incitement. And it is being tolerated.

By failing to grasp the seriousness of what is unfolding, Australia’s political and civic leaders have left the Jewish community standing alone. This abdication of responsibility has sown deep moral confusion. It has set us on a perilous path – one that history warns us never ends well.

The Holocaust did not begin with gas chambers. It began with lies. With distortions. With the portrayal of Jews as uniquely evil. That same dynamic is playing out now.

The collective “Jew”, now equated with Israel, has become a scapegoat for all the world’s ills. The thing that stands between those ills and utopia. And that idea has taken hold here – in our streets, our institutions, even our schools.

This kind of hatred never stays contained. The history is clear: every society that has allowed itself to follow this path has ended up ashamed of where it arrived and inevitably in abject failure.

So we must ask, urgently and clearly: is this really the road we want Australia to go down?

This is not a fringe issue. It is not a moment that can be smoothed over with vague condemnations of “all hate”. It requires leadership. It requires moral clarity. And it requires action now.

Because if we cannot defend the safety and dignity of Jews in Australia today, we will not be able to defend the idea of a tolerant, inclusive, multicultural Australia tomorrow.

Here is the link:

https://www.afr.com/politics/tragic-shift-on-antisemitism-should-terrify-us-all-20250706-p5mctr

All I can add is that we can all do without these ructions disturbing the peace anywhere in Aus!

My view is deportation / goal is ideal for these troublemakers. Confinement for a few years and then deportation seems ideal to me, in that order, for these troublemakers!

David.

Sunday, July 06, 2025

It Seems We Are To Have Another Bout Of All Change Leading To The Same Again – Or Some Such!

This appeared last week:

International, News

Australian Digital Health Agency launches Health Connect Australia Strategy, Architecture and Roadmap

July 1, 2025 11:52 am

The Australian Digital Health Agency has released the Health Connect Australia Strategy, Architecture and Roadmap as part of the launch of the national health information exchange project, Health Connect Australia.

The overall aims of the programme look at improving access to health information between healthcare participants while also addressing the “evolving needs of Australians and healthcare providers” by enhancing the digital infrastructure in place.

Three separate documents have been created to help tackle key challenges around digital health inequity and low digital literacy levels, with the first being based on strategy. It gives an “overview of the strategic intent and goals”, which includes improving access to health information for the right people at the right time, allowing patients to control their healthcare journey, establishing national digital health tools to support health outcomes and making sure information is secure, high quality and addresses privacy concerns.

The agency also focuses on architecture, with an aim “to enhance national digital health interoperability” over the next five years, with 13 different intents outlined, including adopting a consumer-centric approach, supporting local investment and innovation, developing architecturally resilient technical platforms that can accommodate change, approaching technologies and practices with an ecosystem-wide perspective and more.

As well a high-level indicative representation of the roadmap detailed from 2025 to 2030 and beyond is shared. Split by four phases: a foundations phase (2025-2026), which looks at the establishment of a national directory for seamless access to provider information; a sharing phase (2025-2028), focusing on the secure communication of health information between providers and improving consumer access; a discovery phase (2027-2029), working on developing a record discovery service to locate and access healthcare information; and an enhancement phase (2027-2030+), which introduces value-added digital services.

Agency chief clinical adviser (medicine), Dr Amandeep Hansra spoke on the introduction of Health Connect Australia, saying: “The frustration for consumers having to constantly retell their story and clinicians trying to find information such as pathology and diagnostic imaging results, is real, and Health Connect Australia will ensure that a person’s health information moves with them though the system, enabling seamless care.”

Learn more about the Health Connect Australia Strategy, Architecture and Roadmap. (© Australian Digital Health Agency, 2025 Health Connect Australia Strategy, Australian Digital Health Agency.)

Here is the link:

https://htn.co.uk/2025/07/01/australian-digital-health-agency-launches-health-connect-australia-strategy-architecture-and-roadmap/

And we have this – which provided links to some details:

Health Connect Australia Strategy, Architecture and Roadmap

Strategies and plans

The Health Connect Australia Strategy, Architecture and Roadmap articulates the overall architectural vision for creating a digital health ecosystem that enables secure, efficient and standardised information exchange across Australia's healthcare sector. It was developed in consultation with government, industry and peak bodies, and informed by more than 500 items of feedback from key stakeholders. 

The Health Connect Australia Strategy, Architecture and Roadmap consists of 3 key documents:

  • Health Connect Australia Strategy – provides an overview of the strategic intent and goals of the program including its architecture and delivery approach.

Download the Health Connect Australia Strategy (PDF, 1018.7 KB)

  • Health Connect Australia Architecture – outlines a high-level architecture for Health Connect Australia, designed to enhance national digital health interoperability. It provides a foundational framework to guide consistent solution design across the healthcare ecosystem. Further detail on specific technologies and solution architecture will be provided during each program phase.

Download the Health Connect Australia Architecture (PDF, 2.12 MB)

  • Health Connect Australia Roadmap – provides a high-level indicative representation of the program’s phases, including the key outcomes delivered in each phase. It also highlights the prioritised business themes, dependencies and key considerations for the program.

Download the Health Connect Australia Roadmap (PDF, 1.1 MB)

Learn more about Health Connect Australia.

Date last updated: 30 June 2025

Here is the link:

https://www.digitalhealth.gov.au/about-us/strategies-and-plans/health-connect-australia-strategy-architecture-and-roadmap

For oldies like me there is a real sense of déjà-vu with so many of these documents looking like a rehash of previous versions of documents most of us have seen often from many years past!

I suppose there is change – but it really feels to be pretty glacial to me!

As for actual progress and improved delivery of services I will let the reader be the judge!

David.

AusHealthIT Poll Number 801 – Results – 6 July 2025.

Here are the results of the recent poll.

Should Australia Increase Defence Spending To 3% Of GDP?

Yes                                                                     14 (42%)

No                                                                      14 (42%)

I Have No Idea                                                    5 (16%)

Total No. Of Votes: 33

A totally split vote with a few staying out of it!

Any insights on the poll are welcome, as a comment, as usual!

Not bad voter turnout – question must have been decent. 

5 of 33 who answered the poll admitted to not being sure about the answer to the question or wanted to stay out of it!

Again, many, many thanks to all those who voted! 

David.

Friday, July 04, 2025

It Really Seems Like Just Yesterday That Dire Straits Hit Our Consciousness!

This appeared last week:

It is 40 years since we embraced Dire Straits’s Brothers in Arms

Alan Howe

12:00AMJune 28, 2025

When it comes to recorded music, the tail has always wagged the dog; the length of songs has long been dictated by the recording format. The three-minute pop song wasn’t the idea of any artist. It came about because the early recording formats – particularly shellac 78s which exploded in affordable popularity between the wars – ran about that length.

And it stuck fast as radio formats and advertising were tailored to fit. A few longer songs – Don McLean’s American Pie, for instance – were defiantly broken in two with the first half on the A side and finishing when you flipped over the seven inch single. But they were oddities.

Arguably the Beatles’ two most creative albums were Rubber Soul and Revolver, and across them both there are just three songs that are more than three minutes long – one by two seconds, one by seven, the third by 18.

By the time Mark Knopfler’s band Dire Straits started ­recording, longer songs were tolerated by radio, but the band’s debut single, Sultans of Swing, at 5 minutes 47 seconds, was still an exception. Not for Knopfler, though. He has never been inclined to short musical ideas.

Over the next few albums he would take full control of the Dire Straits project. He was already writing all the songs and did so on every album the band recorded and not a moment of it boxed in by commercial radio rules. The first album, produced by Steve Winwood’s brother Muff, had come out of the blue. Their second came out of Nassau in the Bahamas less than a year later. It was a planned project with the Muscle Shoals Sound Studios team of Jerry Wexler and Barry Beckett in the drivers’ seat. This was their American label, Warner Bros, trying to guarantee a winner like its unexpected predecessor. And it was with its hit single, Lady Writer, assumed by many to be a leftover from the first album sessions. I­ndeed, it sounded like it might have been recorded the same day as Sultans of Swing.

Despite the laidback Bahamas seaside setting, Wexler and Beckett brought aspects of that undeniable funk and soul feeling to the sessions even if the Alabama grit didn’t travel. Knopfler’s brawny baritone barks and coaxes the ­storylines out of the music while his 1962 Fender leads its way lyrically and apparently effortlessly through unlikely melodies.

By the next album, Making Movies, Dire Straits was down to a three-piece, Knopfler’s brother David stepping away from the never-ending cycle of album-tour-album leaving bassist John Illsley and drummer Pick Withers. Knopfler co-produced Making Movies with Jimmy Iovine who had just come from making Patti Smith’s Easter album from which came the hit single Because The Night. Perhaps because of Iovine’s connections with Bruce Springsteen and his band, E Streeter Roy Bittan joined in on keyboards, cheekily reprising those first ethereal lines from the storming Jungleland that closed Springsteen’s breakthrough Born To Run album, for the cinematic single Romeo and Juliet. It could well be Knopfler’s finest and most enduring moment.

If he sounds like he means it, it’s because he did. He had just broken up with Holly Vincent, the Chicago-born lead singer of the punk rock band Holly and the Italians. The US outfit had moved to England in 1978 where punk rock was flourishing, but their shallow, derivative sounds – a flimsy mix of punk and new wave – failed to find and audience, and in any case Holly was deported.

But Knopfler’s heart was broken. Good thing, too. It led to the creation of one of the finest rock songs ever written. And it is so beautifully rendered; the arpeggios poured from his 1937 National Resonator guitar and he pulls together lyrical couplets as if he were Jimmy Webb.

When you can fall for chains of silver, you can fall for chains of gold

You can fall for pretty strangers and the promises they hold.

And then referencing West Side Story, that famous New York City retelling of Romeo and Juliet by Leonard Bernstein and Stephen Sondheim:

There’s a place for us, you know the movie song.

When you gonna realise it was just that the time was wrong, Juliet?

But Australians weren’t buying it. Neither, other than in the UK where it rose to No.8 on the charts, was anybody else. It is one of the mysteries of music that such wonderful songs can sometimes pass us by.

But Dire Straits was always an albums band. They have had four No.1 albums in Australia and the worst performed, which was Making Movies, came in at No.6. The other single from it, Tunnel of Love, reached only 62 on the local chart.

Knopfler took over production duties for 1982 Love Over Gold and it showed. Side one had just two songs: Telegraph Road at just over 14 minutes and the single Private Investigations at almost seven. Reluctantly trimmed to just less than six for the single, it must surely rate as one of the most unusual rock songs. Over a glorious guitar melody Knopfler narrates the three verses. It has no chorus. There is a musical interlude of 50 seconds and then he’s back with another line: “Scarred for life, no compensations. Private Investigations.” Knopfler then rates the pain of an untrusting relationship with distant chords until it all fades to nothing.

What could follow? What did is one of the remarkable stories in music. Australians have often defied international trends to adopt albums others overlooked. In 1972 we fell in love with Neil Diamond’s live double album Hot August Night. It had risen to No.5 in the US during a 19-week chart run, and No.32 in a fortnight placing on the UK charts. But across 1973 and 1974 it lodged at No.1 for five months in the Australian charts where it spent 224 weeks. Four years later, Australians adopted Boz Scaggs’ white soul classic Silk ­Degrees album and we were the only country in which it topped the charts staying across 1976 and beyond in a 102-week chart residency.

Forty years ago this month we similarly adopted Dire Straits’ Brothers in Arms. No great effort went into the album artwork, just a striking photo of that treasured 1937 guitar set against a beautiful sunset. But the album entered the charts at No.1 and stayed there for 22 weeks. Then the band toured here – a monster run of 55 dates for which 900,000 tickets were sold. A record broken only recently. Three singles, So Far Away, Money For Nothing and Walk Of Life, charted strongly and Brothers in Arms once again topped the charts for another consecutive 11 weeks. It was the first CD in the world to sell a million copies, and we did our bit; it was the biggest-selling record in Australia in 1985, and the second biggest-selling album the following year.

Brothers in Arms: No great effort went into the album artwork, just a striking photo of that treasured 1937 guitar set against a beautiful sunset.

It has sold 1,225,000 copies here which is 17 times Platinum. It lost out to Phil Collins’ No Jacket Required for the album of the year Grammy – a sin with which The Recording Academy must forever live. It did win Best Engineered Album and the surround sound re-release in 2006 won another. For Knopfler, that year was a whirlwind of concerts – 248 of them starting on April 25, 1985, taking in the London end of Live Aid, and finishing in Sydney with 16 consecutive nights. The tour then moved to Queensland, Perth and even Uluru before returning to Sydney for another four-night stint at the old Entertainment Centre, ending a year and a day later after it had begun.

The songs from Brothers in Arms came to Knopfler at various points, the title song arriving during the Falklands War from a comment his dad made in 1982: “My old man said ‘Isn’t it ironic that the Russians were brothers in arms with the fascist collection of generals in Argentina’. And that’s what put the phrase into my head.”

The band toured repeatedly leading up to the recording of Brothers in Arms. “We were working like trucks. It felt like a 24-hour day shift all the time,” he said, adding that he had to learn to compose songs on the road. “You’d see me walking up a hotel corridor with a chair with no arms on it. It was because there wasn’t one in my room, and I’d gone and found a chair I could play guitar on,” he said laughing at the memory.

The album was mostly recorded over an indulgent three-month stay at George Martin’s small AIR studios on Montserrat in the West Indies. It had the latest 24-track digital tape machine desks. But some of the new tapes were faulty and three tracks had errors on some channels. These were finished off at the Record Plant on Manhattan, giving Knopfler the chance to add some of the sophisticated brilliance of the Brecker brothers, Randy and the late Michael, to add trumpet and sax to Your Latest Trick. Two years before, Michael’s sax had also defined the glorious melody Knopfler wrote for Going Home, from the Local Hero soundtrack. “He’s just got New York in that sound in that sax. I don’t think he’s actually ever been equalled,” Knopfler said of the virtuoso who stood tallest in narrow canyons of Manhattan’s brass-section giants.

English rock band Dire Straits performing in concert at Football Park, South Australia, in 1986. Lead singer guitarist Mark Knopfler, right

Terence Williams, who’d replaced Withers on drums, played on all the Montserrat recording, but was uneasy about his contributions and flew home to make way for David Bowie’s drummer Omar Fakim who’d earlier made his name in Weather Report. But Williams’ fierce drum intro to Money for Nothing stayed. But not everything did: weeks after Brothers in Arms was released Knopfler and Sting performed it at Live Aid with Knopfler changing the word “faggot” to “queenie” and later “maggot”.

Knopfler remembers the Australia legs of that tour well.

“I like the smell of Australia,” he said. “I loved it there. It became a bit of a break for us. I still treasure my time there.”

Dire Straits had toured in 1981 and 1983 and Knopfler had become friends with eccentric Sydney artist Brett ­Whiteley and had seen his dramatic, 18-pannelled Alchemy work which these days can sometimes be seen at the Art Gallery of NSW in all its 16m glory. Knopfler had adapted some of the cover of his 1984 double live album of the same name.

“I think Brett was always very, very interested in what was happening in the rest of the world,” Knopfler says on a Zoom call from London. He agrees Whiteley was a bit bonkers. “Oh, yeah. Brett was Brett, bless him. He was bright, bright”, he says of the artist who died in 1992 at the age of 53 of a drug overdose. “I don’t ever think he was looking for a way out because absolutely he wasn’t.”

Sydney Entertainment Centre secret facts playing cards featuring artists, such as Dire Straits (pictured), who have played concerts at the venue. The Card set was found during the demolition of the Sydney Entertainment Centre. Picture: John Fotiadis

Just before he died, Whiteley had told Knopfler that “he was looking forward to his Paris show – which was tremendous – and he was looking forward to something else in painting and exhibitions. So he was really enthused by what he was doing. He just made a stupid mistake.”

Knopfler maintains many friends here in Australia and particularly likes Rushcutters Bay in Sydney, a short stroll down from Elizabeth Bay’s Sebel Townhouse where the band stayed for so many weeks as the city fell in love with seeing them live.

He tells me his sister, who lives in England, still buys him his favourite chocolate bar. “She goes out to a special candy sweet shop and buys those raspberry ripply things that get made in Australia and gives them to me. It’s the taste of Australia!”

I have never before heard a Cherry Ripe described in that way, but I understood.

MAKING MAGIC WITH BOB DYLAN

Mark Knopfler’s good friend from his early days was Steve Phillips, a blues enthusiast, guitarist, instrument builder and painter. In The Gallery, a song from Dire Straits’ first album, was about Phillips’ sculptor father Harry. Phillips’s mother was a painter. Phillips is the bloke who bought that National guitar which, of course, shines like the Mississippi Delta across so many of Knopfler’s songs.

That was in the 1960s when Phillips played around Leeds pubs and at one point was interviewed by a young reporter called Knopfler. They became friends and Phillips introduced his mate to older American blues. Years later, Phillips would record some of it, including songs written by Blind Willie McTell (below). “It was a tremendous broadening of my knowledge,” said Knopfler of playing and rehearsing with Phillips. “My finger-picking became more refined and more and more bluesy. I was going forward with jazz a little bit, going forward with chords on the one hand, and on the other going backwards into the past with the National and with other string instruments.”

It was timely training. By 1977, Knopfler had formed Dire Straits. They recorded their debut album in a deconsecrated church in London in February the following year and by early 1979 had the single Sultans of Swing climbing charts worldwide and were performing small venues in Los Angeles where, on February 28, 1979, Bob Dylan went to see them at the late show at the Roxy.

Dylan’s concerts and records had been poorly received for a few years and, the man who believed Christ had visited him in a Tucson hotel the year before, was bent on making changes to his life – and certainly to his sound. He went backstage and asked Knopfler to help out on his next album which would be the Christian/folk/blues music shock that was Slow Train Coming.

Knopfler was back to work on Dylan’s Infidels in 1983, an album they co-produced and on which should have been perhaps Dylan’s most exquisitely perfect composition – a stark, melancholy, lyrically absolute song Dylan had just written called Blind Willie McTell. Just the two of them: Knopfler on an acoustic 12-string and Dylan on piano. The dull foot tapping throughout is Knopfler’s.

McTell himself had been recorded by musicologist John Lomax who, apart from teaching himself ancient Greek and Latin, realised before anyone else the invaluable contribution to American music that had been made by black American cowboys. He and his sons John Jnr and Alan spent their lives recording the music that was already fading from American life and whose practitioners were dead, in jail or otherwise silenced.

McTell’s thin volume of music – he died in 1959 – is a jaunty mix of blues and country and perhaps with hints of Scott Joplin. One of his songs to survive – with that distinctive clear, penetrating vocal – is Statesboro Blues which has been recorded by Taj Mahal, David Bromberg and was famously part of most Allman Brothers’ sets. ­English folkie Ralph May recorded it before changing his surname to McTell.

Dylan’s song traces lines in American history from slavery, chain gangs, hostile Confederate “rebel yells” to the Civil War and the burning of rundown plantations after it when the cheap labour that sustained them dried up.

For Dylan, “God is in His heaven” but man proved himself untrustworthy in the Garden of Eden through “power and greed and corruptible seed”. Knopfler too was struck by this composition’s undecorated beauty. “I love that song,” he said. Indeed, they had been discussing influences with Dylan “who was big into Robert Johnson, and I said ‘do you listen to Blind Willie McTell?’. It could be that I put Blind Willie McTell into Bob’s head”.

Indeed it could. It’s not a song about McTell (pictured left), it is just a device to link the verses together, and unlike Johnson, McTell rhymes with lots of words. Dylan clearly thought he had never nailed the song he heard in his head. There are three versions of it about, the one with Knopfler that came out on the Official Bootleg Series, another with the Rolling Stones’ Mick Taylor on slide, and a third yet-to-surface version, of which Knopfler said: “I did (it) with electric guitar and piano. I don’t know what happened to that, which was really spaced out.”

On May 5, 1983, Dylan and Knopfler recorded it a final time, a hauntingly spare rendition. Still Dylan was unhappy. He never returned to that song. It sounds like another manufactured myth of Dylanology to point out that it would have been Blind Willie’s 80th birthday.

Alan Howe

Here is the link:

https://www.theaustralian.com.au/arts/review/it-is-40-years-since-we-embraced-dire-straitss-brothers-in-arms/news-story/935d211b4a46c31fef97551c069ffb76

The track (Telegraph Road) is on YouTube here:

https://www.youtube.com/watch?v=jhdFe3evXpk

The sound-track of my PhD! – was introduced to them by my research assistant and never looked back!

What with doing all my training I missed them until started doing my PhD research by which time they were “old hat”! A very great band IMVHO!

David.

Thursday, July 03, 2025

Finding New, Safe And Effective Drugs Is A Major And Important Health System Activity

This appeared last week:

Even a sceptic can see AI will transform the discovery of drugs

Tom Whipple

At every stage in the drugs pipeline there are ways in which AI could, in theory, make it less leaky.

10:00 AM March 29, 2025.

If you haven’t got idiopathic pulmonary fibrosis, ISM001-055 may not seem immediately interesting. In truth the molecule, designed to treat the lung condition, may not even seem that interesting if you do.

A study last month into its effectiveness in about 80 people was written in typically cautious language. The side effects weren’t awful. There were hints it improved lung function. The main conclusion was that there was enough evidence to justify collecting more evidence.

And the reason we should indeed be interested? It was found and designed using AI.

The drug is less an attempt by Insilico, the company behind it, to solve a rare lung disease than to tackle a widespread industry disease.

Today, getting a new drug costs £2 billion ($4.2bn). Of molecules considered promising enough to enter one end of the trial pipeline, 10 per cent emerge successful from the other. Computers have Moore’s law, the idea that performance doubles every couple of years. Pharma has Eroom’s law, the idea that drug discovery does the reverse.

ISM001-055 is a bet Eroom will end. Since the release of ChatGPT, we have used AI to write coursework, write generic PowerPoints and write bad poetry in the style of a pirate. In that time, in parallel, there has been a different, actually useful AI revolution. It seeks not to understand language but biology.

At every stage in the drugs pipeline there are ways in which AI could, in theory, make it less leaky. Currently, we seek drug targets through intuition and experimental data. AI, in theory, allows us to understand what is actually happening at the level of the protein. These are the molecular machines in cells whose structure determines their function but which for so long had structures that were fiendishly hard to determine.

AI, again in theory, allows us to map and parse the fiendishly complex metabolic pathways involving those proteins that, if they go wrong, are what we call “disease”.

Today, to get a drug, scientists look for plausible molecules we know of, screen them, then hope one does something to those proteins that is useful. AI potentially allows us to pick molecules from the 1080-odd possibilities, choosing those most likely to lock into the protein we want.

Will it work? ISM001-055 is the furthest such an AI-made drug has got. Insilico is not alone in betting on others getting further. The UK government announced a project to gather data on how drugs interact with proteins, to train models to identify new drugs and “slash development costs by up to pounds 100 billion”. If that sounds over-ambitious, Demis Hassabis, chief executive of Google DeepMind and Isomorphic Labs, Google’s AI drug company, goes further. He thinks AI will cure all diseases in a decade.

Absurd? It certainly sounds it to me. It also sounded absurd, though, when he suggested that within 10 years AI would be able to make a good guess at the structure of every protein, a grand challenge of biology that would all but guarantee someone got the Nobel. Well, today Hassabis is the someone with the Nobel.

But it doesn’t much matter if you think this has the whiff of hype. Currently, 90 per cent of drugs fail. If we get that to 80 per cent through AI we will have doubled our effectiveness. Humans are sufficiently bad at drug discovery that the bar for AI success is very low indeed.

The Times

Here is the link:

https://www.theaustralian.com.au/health/medical/even-a-sceptic-can-see-ai-will-transform-the-discovery-of-drugs/news-story/3e85ccb81b45c40186f7dcbd4a589d48

All I can do is wish all the boffins the best of luck in finding the molecules that work safely and effectively!

 Zillions of lives have been saved or enhanced by what has been done to date and there is no reason for things to change! AI is surely going to help all the efforts for the good of all!

David.

Wednesday, July 02, 2025

Clearly Chatbots Are Providing Something Much Worse Than Harmless Fun…

This appeared last week:

Experts alarmed over chatbot harm to teens

Marcus de Blonk Smith

12:00AMJune 28, 2025

AI chatbots are more dangerous to Australian teenagers than social media and YouTube, with the technology being linked to the suicide and radicalisation of teens overseas, experts warn.

Australia late last year passed groundbreaking legislation aimed at preventing anyone under the age of 16 from registering to join social media platforms, including Facebook, Instagram, X and Snapchat – and this week there were calls for the popular video-sharing app YouTube to be added to the ban.

There is also a push among some experts to extend the legislation to include generative AI companions and bots, with concerns about the manipulative nature of the technology.

A Florida mother in 2024 sued chatbot creator Character.ai, claiming it contributed to her 14-year-old son’s suicide.

Megan Garcia alleged the AI chatbot app had “abused and preyed on my son, manipulating him into taking his own life”.

In 2023, a UK court sentenced a 21-year-old man to nine years in jail for breaking into Windsor Castle with a crossbow. The trial heard how Jaswant Singh Chail had exchanged more than 5000 messages with an online companion he’d named Sarai, which included discussions about how he wanted “to assassinate the queen of the royal family”.

In an interview with The Australian, leading men’s health expert and clinical psychologist Zac Seidler warned the technology was being “weaponised” against young men.

The fact this technology “is being weaponised against young men, and the fact that their likelihood and impulse control and risk taking makes them more at risk for suicide and self-harm is really, really concerning”, he said.

Dr Seidler said AI chatbot platforms, which were “popping up everywhere”, were “purposefully going to create harm” and “exacerbate symptoms of disconnection and depression over time among young men”.

“If it continues with the trends that we’re witnessing at the moment, I am really concerned that this could get very, very bad in ways we can’t even see right now,” he said.

Mhairi Aitken, a senior ethics fellow at the Alan Turing Institute, said AI technologies had not been designed in ways that were safe for children, adding the risks were, in many ways, “much more dangerous” than social media.

“The risk here is that it’s exacerbating or amplifying a lot of the risks and harms of social media,” she said.

“We should have learned the lessons … there’s a real risk that this is repeating (those same mistakes) and potentially in a worse way.”

Toby Walsh, a leading expert in artificial intelligence at the University of NSW, agrees.

He says “we should be very concerned” at the development of companion AI chatbots, adding that “social media should’ve been a practice run”.

“We’re about to run another experiment on our young children and potentially the consequences could be quite detrimental,” he said.

Professor Walsh urged politicians and regulators to closely consider banning the technology, which would “incentivise the tech companies to build age-appropriate spaces for young people”.

“There’s a lot of money at stake and there’s a lot of commercial pressure for them to do this,” he said.

“The only way to alleviate that pressure is to outlaw it if they’re not going to do the right thing.”

Meetali Jain, director and founder of the non-profit Tech Justice Law Project, said she was not in favour of banning the technology, but instead would like “to see a change in how Silicon Valley does business”.

“As the mother of two children myself, it’s really frightening,” she told The Australian.

“The more I’ve started to learn about companion chatbots, it terrifies me in ways that I never thought possible with social media.”

Ms Jain was contacted in May last year by Ms Garcia, and said the Florida mother had a hard time being believed and finding support for legal representation, and she had decided “to jump into it” and represent her, helping to draft a complaint.

Since launching Ms Garcia’s case in October in the federal courts in Florida, other families had come forward, Ms Jain said, adding that she was now representing three families who were alleging that AI companion chatbots had caused their children “pretty grievous harm”.

Asked what concerned her most about AI chatbots, Ms Jain said it was the fact the technology was being developed “under our nose in plain view, and yet we didn’t even know about it”.

She added: “I had a parent asking me a few months ago, ‘Do I know any sex addiction therapists for her 11-year-old?’”

Australian Psychological Society president Sara Quinn said she was “gravely concerned” about the potential harms of the technology for young people.

Dr Quinn called for a “comprehensive framework in Australia” and “more rigorous oversight from tech companies” to ensure that these tools were safe for children.

Speaking at the National Press Club on Tuesday, eSafety Commissioner Julie Inman Grant flagged that Australia’s social media ban would not address emerging AI harms for young people, but said the unregulated use of AI companions was of particular concern.

“The rise of powerful, cheap and accessible AI models without built-in guardrails or age restrictions are a further hazard faced by our children today,” she said.

In a statement, Ms Inman Grant told The Australian that eSafety had “been monitoring the rise in popularity” of AI chatbots and had “taken a number of steps to inform parents about the risks”.

“It is important that parents are aware these apps are out there and talk to their children as much as possible about their online activities,” she said.

Ms Inman Grant added that work was under way “to protect children from online harms associated with generative AI”.

Do you know more? Confidentially contact marcus.deblonksmith@news.com.au

Here is the link:

https://www.theaustralian.com.au/nation/experts-alarmed-over-chatbot-harm-to-teens/news-story/7d721c70a1ff1991989f103ec46fe20d

All in all a salutary tale about just what can go wrong with technology if implemented without careful observation of the outcome(s).

The pace of innovation is such that I suspect we will always be rather behind the consequences of implementation than we may see – rather than being ahead of the curve!

David

Tuesday, July 01, 2025

This Has To Really Be The Most Awful Potential Fate Hanging Over Any Family

This appeared last week:

Three Siblings, One Fatal Gene: A Family’s Fight Against Early-Onset Alzheimer’s

Among members of the Richardson family who carry a mutation in the PSEN1 gene, the average age when symptoms start is unthinkably young.

Dominique Mosbergen

Dow Jones

Hannah Richardson is hopeful about her future and its endless possibilities. But the 24-year-old’s plans are clouded by an unthinkable reality – there is a 50 per cent chance she will develop Alzheimer’s disease in her 30s.

Hannah’s family has a history of a rare genetic mutation that, when inherited, virtually guarantees that the carrier will die of an aggressive form of Alzheimer’s early in life. No drug has been found to stop it. But now researchers are exploring a new avenue: Could pre-emptive treatment slow or even halt the memory-robbing disease in people at high risk of developing it?

Hannah and her two siblings will help researchers test that theory. They are enrolling in a new clinical trial led by doctors at the Washington University School of Medicine. As part of the trial, the siblings will finally find out if they carry the fatal gene.

“I don’t know if being in the trial is going to save me or my siblings. But in my head, it’s the least I can do. Research is how cures are found, ” said Hannah, who dreams of becoming a physician assistant and is applying to graduate programs. Her brother Jacob, 22, and sister Rylee, 19, are both in college.

Unlike most cases of Alzheimer’s, which are unpredictable, “in this population we know who will develop the disease and when they will develop it,” said Heather Snyder, senior vice president of medical and scientific operations at the Alzheimer’s Association, a major funder of the trial.

Doctors have identified over 300 inheritable genetic mutations that cause early-onset Alzheimer’s. These rare genes account for less than 1% of people with the condition, but researchers say that studying families like the Richardsons can offer insights into how to prevent and treat Alzheimer’s in everyone.

Among the people in Hannah’s family who carry a mutation in what is known as the presenilin-1, or PSEN1, gene, the average age when Alzheimer’s symptoms start is 39, according to the family. The disease is aggressive once symptoms appear and the decline is swift, the family said.

“I call it the monster,” said Mary Salter, Hannah’s grandmother. Hannah’s grandfather and three of his four brothers died of Alzheimer’s in their early 40s, soon after developing symptoms. Hannah’s uncle died last year of the disease at the age of 44. And Hannah’s mother, Carrie Richardson, started showing subtle signs of the disease in her early 40s. Now at age 44, Carrie has started to decline mentally.

Carrie’s children remember vividly the day in 2012 when she learned she was a carrier of the PSEN1 mutation. Her eyes were red and puffy when she picked the kids up from school. Pressed by Hannah to tell them why, a sobbing Carrie told them the news in the car. The siblings, who were all under 12, remember crying, too, though not fully understanding why.

Today, Carrie has memory lapses and sometimes struggles to communicate, her children say. Her worsening symptoms forced her to quit her job as a preschool teacher and this month, she started the process of leaving her own home to move in with Mary.

Carrie and her brother enrolled in a clinical trial that began at WashU Medicine in 2012. That trial tested whether the early use of experimental drugs that target a sticky protein in the brain known as amyloid could slow the progression of Alzheimer’s in people who carried PSEN1 mutations and other rare genes. Hannah’s uncle hadn’t been able to join an extension of the trial because his symptoms became too pronounced, but her mum continues to be a participant and receives a bimonthly infusion of an antiamyloid drug.

In a paper published in Lancet Neurology in March that detailed interim results of the extended trial, WashU Medicine researchers said treating people like Hannah’s mum with antiamyloid drugs before Alzheimer’s symptoms began, delayed the onset of the disease — in some cases lowering participants’ risk of developing symptoms by 50 per cent.

The first antiamyloid drugs were approved by the Food and Drug Administration in 2021. These drugs clear accumulations, or plaques, of amyloid in the brain, which researchers once thought could be the root cause of Alzheimer’s. But some doctors have since questioned this hypothesis, as well as whether the benefits of these treatments outweigh their risks.

The drugs don’t stop Alzheimer’s in its tracks and though they have shown to reduce cognitive decline in some large clinical trials, the slowing was modest at best, said Dr. Scott Small, a Columbia University neurologist.

“The science now predicts that amyloid plaques are not the root source of Alzheimer’s,” Small said.

Swelling and bleeding in the brain is a possible side effect of antiamyloid drugs. Rarely, people have died from this complication. In about half of all patients in the WashU Medicine study, some brain swelling and microbleeds were detectable in MRI scans, though researchers said about 95% of participants had no symptoms from the medications.

Antiamyloid drugs remain the only FDA-approved treatment available that can change the course of Alzheimer’s. Dr Randall Bateman, a neurologist who led the WashU Medicine study, said early use of the treatments could improve their efficacy and safety. He said he remains optimistic that removing — or even preventing altogether — the build-up of amyloid could slow or even halt the progression of the disease.

Hannah and her siblings believe that antiamyloid drugs have helped stall their mum’s Alzheimer’s. That belief spurred them to enrol in a similar WashU Medicine clinical trial — one that seeks to treat carriers of rare genes with a different experimental antiamyloid drug, called remternetug, many years before they develop symptoms and, in some cases, even before amyloid has built up in their brains. Drugmaker Eli Lilly, which makes the drug, said it works similarly to earlier antiamyloid treatments but has the benefit of being administered as an injection rather than an intravenous infusion.

Rylee Richardson, a cheerleader and rising sophomore at Tulane University, said she and her siblings thought long and hard about participating in the trial. They ultimately decided that it was worth the potential risks.

“I will do anything that gives me and my siblings a better chance,” she said. Until now, Rylee and her siblings had decided not to find out if they carry the PSEN1 mutation out of fear that it could up-end their lives. But if they want to participate in the extended phase of the trial, they will have to learn the truth. The initial phase will last for two years and focus on basic efficacy and safety questions, said Dr. Eric McDade, a colleague of Bateman’s who is leading the trial.

Only people who test positive for a high-risk genetic mutation will be randomised to either receive a low dose of the active drug or placebo. For those who test negative, they can stay in the trial if they choose not to find out their genetic status and would be given a placebo.

Dr Richard Isaacson, a neurologist at the Institute for Neurodegenerative Diseases who isn’t involved in the trial, said he believes antiamyloid drugs could be helpful in slowing cognitive decline when used preventively in patients at risk of Alzheimer’s. He himself prescribes them to patients at his clinics in New York and Florida, but only in people who already have some amyloid build-up. He questioned whether it made sense to use these drugs in people who don’t have amyloid at all.

“That is not something that sits well with me,” said Isaacson. WashU Medicine researchers said that in animal experiments, antiamyloid treatments were most effective when used before evidence of amyloid build-up. But such an experiment has yet to be conducted in people.

Alzheimer’s has been a spectre that has haunted the Richardson siblings since they were children. The three of them made a pact years ago to not have children if they learned that they carried the Alzheimer’s gene.

“We decided that we would be the last three. No one has to suffer anymore from our family,” Hannah said. “We want to do everything we can to stop it for us and everybody else.”

Wall Street Journal

Here is the link:

https://www.theaustralian.com.au/health/medical/three-siblings-one-fatal-gene-a-familys-fight-against-earlyonset-alzheimers/news-story/267367843d5555748d7e957c9fe0a6ab

This is an awfully sad story which it seems those involved are approaching with considerable courage and insight.

It is hard to imaging being caught in such a horrible fate and I find the whole set of circumstances deeply confronting.

I am not sure I would be as stoic if I was caught in such a saga!

David.